Abstract #0966

Impact of exercise intervention on vascular function in PAD

Erin K Englund¹, Michael C Langham², Thomas F Floyd³, Felix W Wehrli², and Emile R Mohler⁴

¹Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, ²Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ³Department of Anesthesiology, Stony Brook University, Stony Brook, NY, United States, ⁴Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Peripheral vascular function can be interrogated by measuring recovery dynamics following induced ischemia. In this study, 136 patients with peripheral artery disease were randomized into supervised exercise rehabilitation (SER) or standard medical care (SMC). Each patient’s leg was scanned before and after the intervention period. MRI data were acquired throughout an ischemia-reperfusion paradigm with PIVOT, a method to simultaneously and dynamically measure perfusion, venous oxygen saturation, and skeletal muscle T₂*. Patients randomized to SER had a significant increase in peak perfusion from baseline to follow-up when averaged across the entire cross-section of the leg and in the peroneus muscle.

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