Abstract #0967

MRI biomarkers associated with guide wire puncture forces required to cross ex-vivo human peripheral arterial chronic total occlusions

Trisha Roy^1,2, Garry Liu¹, Noor Shaikh¹, Kevan Anderson¹, Nicolas Yak¹, Xiuling Qi¹, Andrew Dueck^1,2, and Graham Wright^1,3

¹Schulich Heart Program and the Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ²Division of Vascular Surgery, University of Toronto, Toronto, Canada, ³Department of Medical Biophysics, University of Toronto, Toronto, Canada

Percutaneous vascular interventions (PVI) for treating peripheral arterial disease (PAD) have poor outcomes with high re-intervention and failure rates. Not all lesions are amenable to PVI, but predicting failure is difficult. While CT can identify heavily calcified lesions, current imaging offers limited differentiation between hard and soft PAD plaques, which impacts procedural success. This study demonstrates the feasibility of using MRI biomarkers to characterize plaque components in ex-vivo human peripheral arteries with histologic and microCT validation. We demonstrate that significantly higher puncture forces are required to cross non-calcified “hard” chronic total occlusions (CTOs) compared to “soft” CTOs, as classified by these MRI biomarkers.

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