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Abstract #0967

MRI biomarkers associated with guide wire puncture forces required to cross ex-vivo human peripheral arterial chronic total occlusions

Trisha Roy1,2, Garry Liu1, Noor Shaikh1, Kevan Anderson1, Nicolas Yak1, Xiuling Qi1, Andrew Dueck1,2, and Graham Wright1,3

1Schulich Heart Program and the Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 2Division of Vascular Surgery, University of Toronto, Toronto, Canada, 3Department of Medical Biophysics, University of Toronto, Toronto, Canada

Percutaneous vascular interventions (PVI) for treating peripheral arterial disease (PAD) have poor outcomes with high re-intervention and failure rates. Not all lesions are amenable to PVI, but predicting failure is difficult. While CT can identify heavily calcified lesions, current imaging offers limited differentiation between hard and soft PAD plaques, which impacts procedural success. This study demonstrates the feasibility of using MRI biomarkers to characterize plaque components in ex-vivo human peripheral arteries with histologic and microCT validation. We demonstrate that significantly higher puncture forces are required to cross non-calcified “hard” chronic total occlusions (CTOs) compared to “soft” CTOs, as classified by these MRI biomarkers.

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