Abstract #0970

In vivo localization and timing of oxygen delivery in human placenta based on BOLD MRI

Jie Luo^1,2, Esra Abaci Turk^1,2, Polina Golland^3,4, Borjan Gagoski¹, Carolina Bibbo⁵, Drucilla J Roberts⁶, Norberto Malpica⁷, Julian N Robinson⁵, Patricia Ellen Grant¹, and Elfar Adalsteinsson^2,3,8

¹Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States, ²Madrid-MIT M+Vision Consortium in RLE, Massachusetts Institute of Technology, Cambridge, MA, United States, ³Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁴Computer Science and Artificial Intelligence Laboratory (CSAIL), Massachusetts Institute of Technology, Cambridge, MA, United States, ⁵Maternal and Fetal Medicine, Brigham and Women's Hospital, Boston, MA, United States, ⁶Obstetric and Perinatal Pathology, Massachusetts General Hospital, Boston, MA, United States, ⁷Medical Image Analysis and Biometry Laboratory, Universidad Rey Juan Carlos, Madrid, Spain, ⁸Harvard- MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

Clinically there is no direct measurement of oxygen delivery in placenta. In this study, we propose a method to map the timing of oxygen delivery in the human placenta in vivo. Healthy placentae show pn that agree with normal perfusion timing in response to maternal hyperoxygenation. Pathological placentas exhibit a more dispersed timing across the placenta. Better understanding of the timing in different type of pathology may be achieved by spatial correlation between placental pathology and in vivo placenta images in both healthy and pathological placenta based on BOLD signal change in response to maternal hyperoxygenation.

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