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Abstract #0971

Placental vascularization quantification using ex-vivo magnetic resonance angiography

Bailiang Chen1,2,3, Jie Duan2,3,4, Jacques Felblinger1,2,3,5, Olivier Morel2,3,4, and Marine Beaumont 1,3,5

1CHRU Nancy, CIC-IT 1433, Inserm, Vandoeuvre-lès-Nancy, France, 2Imagerie Adaptative Diagnostique et Interventionnelle, Université de Lorraine, Nancy, France, 3U947, Inserm, Nancy, France, 4Service d’obstétrique et médecine fœtale, Pôle de Gynécologie-Obstétrique, CHRU Nancy, Nancy, France, 5Pôle S2R, CHRU Nancy, Nancy, France

Abnormal uteroplacental vascurlarization can cause major obstetric complications such as intra-uterine growth restriction or abnormally invasive placenta. Clinical 3D ultrasound imaging cannot discriminate maternal and fetal flow in utero-placental unit, thus blocking a better understanding of the pathology. Conventional ex-vivo vascularization quantification relies on 2D histological slices using samples dissected from placenta. Micro-CT was applied to fixed small animal placenta but with complicated and long preparation. Here we presented the flexibility of a comprehensive 3D vascularization characterization of a fresh healthy human placenta using ex-vivo MRA. A quantification framework is proposed with defined systematic metrics to characterize the vascularization.

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