Abstract #0980

Discrimination of COPD Patients, Healthy Smokers and Age-matched Normals with Hyperpolarized Xenon-129 MR Spectroscopy

Kai Ruppert^1,2, Kun Qing², Talissa A. Altes^2,3, and John P. Mugler III²

¹Cincinnati Children's Hospital, Cincinnati, OH, United States, ²University of Virginia, Charlottesville, VA, United States, ³University of Missouri, Columbia, MO, United States

Chemical Shift Saturation Recovery (CSSR) MR Spectroscopy permits the in-vivo measurement of the alveolar septal wall thickness (SWT) by quantifying the uptake of hyperpolarized xenon-129 by lung parenchyma on a millisecond timescale. In this study we correlated the SWT with apparent diffusion coefficient (ADC) measurements in patients with chronic-obstructive pulmonary disease (COPD), healthy smokers and age-matched normals. While the ADC measurements and conventional pulmonary function tests could detect statistically significant differences between the COPD and non-COPD subjects, only CSSR spectroscopy could, in addition, discriminate healthy smokers from the age-matched normals.

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