Abstract #0979

Comparison of 3He and 129Xe MRI for Evaluation of Lung Microstructure and Ventilation in Healthy Volunteers and COPD Patients at 1.5 T

Neil James Stewart¹, Ho-Fung Chan¹, Guilhem Jean Collier¹, Felix Clemens Horn¹, Graham Norquay¹, Juan Parra-Robles¹, Denise Yates², Paul Collini³, Rod Lawson⁴, Helen Marshall¹, and Jim Michael Wild¹

¹Academic Unit of Radiology, University of Sheffield, Sheffield, United Kingdom, ²Novartis Institutes for Biomedical Research, Cambridge, MA, United States, ³Academic Unit of Immunology and Infectious Diseases, University of Sheffield, Sheffield, United Kingdom, ⁴Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom

³He and ¹²⁹Xe ventilation and diffusion-weighted MR images were acquired at 1.5T in healthy volunteers and, at multiple time-points, in COPD patients in order to compare the functional sensitivity and assess the repeatability of MR-derived measures of ventilated volume (VV%) and apparent diffusion coefficient (ADC) from each of the two gases. ADC values from both nuclei exhibited excellent agreement and significant correlations with pulmonary function tests (PFTs) (p<0.001), whilst VV% values were less comparable. ADC and VV% metrics derived from both nuclei were also shown to be repeatable, with coefficient of variation values similar to those of PFTs.

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