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Abstract #0979

Comparison of 3He and 129Xe MRI for Evaluation of Lung Microstructure and Ventilation in Healthy Volunteers and COPD Patients at 1.5 T

Neil James Stewart1, Ho-Fung Chan1, Guilhem Jean Collier1, Felix Clemens Horn1, Graham Norquay1, Juan Parra-Robles1, Denise Yates2, Paul Collini3, Rod Lawson4, Helen Marshall1, and Jim Michael Wild1

1Academic Unit of Radiology, University of Sheffield, Sheffield, United Kingdom, 2Novartis Institutes for Biomedical Research, Cambridge, MA, United States, 3Academic Unit of Immunology and Infectious Diseases, University of Sheffield, Sheffield, United Kingdom, 4Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom

3He and 129Xe ventilation and diffusion-weighted MR images were acquired at 1.5T in healthy volunteers and, at multiple time-points, in COPD patients in order to compare the functional sensitivity and assess the repeatability of MR-derived measures of ventilated volume (VV%) and apparent diffusion coefficient (ADC) from each of the two gases. ADC values from both nuclei exhibited excellent agreement and significant correlations with pulmonary function tests (PFTs) (p<0.001), whilst VV% values were less comparable. ADC and VV% metrics derived from both nuclei were also shown to be repeatable, with coefficient of variation values similar to those of PFTs.

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