Abstract #0987

Cardiac Magnetic Resonance Reveals Signs of Subclinical Myocardial Inflammation in Asymptomatic HIV-infected Patients

Julian Alexander Luetkens¹, Jonas Doerner¹, Carolynne Schwarze-Zander², Jan- Christian Wasmuth², Christoph Boesecke², Alois M Sprinkart¹, Frederic C Schmeel¹, Rami Homsi¹, Juergen Gieseke³, Hans H Schild¹, and Claas P Naehle¹

¹Radiology, University of Bonn, Bonn, Germany, ²Internal Medicine I, University of Bonn, Bonn, Germany, ³Philips Research, Hamburg, Germany

People living with chronic human immunodeficiency virus (HIV) infection are at an increased risk for cardiovascular disease. In the present study we investigated HIV-infected patients, which were controlled for the disease, using multiparametric cardiovascular magnetic resonance (CMR). With this CMR approach we could demonstrate that HIV-infected patients without cardiac symptoms not only have subtle evidence of impaired myocardial function, but also elevated markers of myocardial inflammation and increased myocardial fibrosis. These findings indicate subclinical myocardial inflammation in HIV-infected patients despite effective antiretroviral therapy, and therefore may contribute to the persistently increased cardiovascular morbidity and mortality observed in these patients.

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