Abstract #0988

MR Imaging of Liver Microstructure in Hepatic Fibrosis and Cirrhosis at 11.7 T

Mark Valasek¹, Qun He^2,3, Claude Sirlin², Graeme M. Bydder², and Nikolaus M. Szeverenyi²

¹Pathology, University of California, San Diego, San Diego, CA, United States, ²Radiology, University of California, San Diego, San Diego, CA, United States, ³Ningbo Jansen NMR Technology Co., Ltd., Cixi, Zhejiang, China, People's Republic of

We performed MR microscopy at 11.7 T to examine the tissue structure of normal, fibrotic and cirrhotic liver samples. Images having 100-1,000 times the spatial resolution of clinical MR images were obtained in small tissue samples using an animal imaging system with appropriately small custom T/R solenoid coils. Diffusion imaging with three direction of sensitization revealed sheet like fibrous structures, exhibiting high signal intensity in regions where the sensitization direction was orthogonal to a sheet.

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