Abstract #0991

Regional cardiac mechanical activation times using cine DENSE strain imaging strongly predict electrical activation times in cardiac resynchronization therapy

Daniel A Auger¹, Kenneth C Bilchick², and Frederick H Epstein^1,3

¹Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, ²Department of Medicine, Cardiovascular Medicine, University of Virginia, Charlottesville, VA, United States, ³Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States

A widely held goal in cardiac resynchronization therapy (CRT) is to implant the left-ventricular (LV) pacing lead in a late-activating region. Time to peak shortening (TPS) has been used to image mechanical activation; however electrical activation time is directly related to the time of onset of contraction rather than TPS. Using cine DENSE in heart failure patients, we show that the time of onset of shortening (TOS) shows a strong correlation with electrical activation time, whereas a lower correlation was found using TPS. Cine DENSE of TOS is a promising method for the detection of late-activating segments in CRT patients

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