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Abstract #0997

Comprehensive assessments of myocardial tissue kinetic parameters of K1, k2, MBF, lambda and ECV by using a synergistic quantitative analysis of first-pass myocardial perfusion MRI and pre-and post-contrast T1 mapping in patients with myocardial infarction.

Akimasa Yamada1, Masaki Ishida1, Takashi Ichihara2, Takahiro Natsume2, Yoshitaka Goto1, Mio Uno1, Motonori Nagata1, Yasutaka Ichikawa1, Kakuya Kitagawa1, and Hajime Sakuma1

1Radiology, Mie University Hospital, Tsu-Mie, Japan, 2Faculty of Radiological Technology, Fujita Health University School of Health Science, Toyoake-Aichi, Japan

In this study, we proposed a new method that synergistically analyzes quantitative perfusion MRI and T1-mapping for quantifying k2, as well as K1, myocardial blood flow, lambda and extracellular volume fraction. Nineteen patients with previous myocardial infarction (MI) were studied. Myocardial segments were categorized into 3 groups by presence or absence as well as severity of MI in each segment. Quantitative measurement was successful in all segments with significant difference among the 3 groups of myocardial segments for all tissue kinetic parameters including k2. Synergistic assessment of quantitative perfusion MRI and T1-mapping is promising for more detailed myocardial tissue characterization.

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