Abstract #0996

Towards Reliable Non-Contrast Enhanced MR-based Myocardial Perfusion Imaging: Myocardial BOLD MRI Using Late Effects of Regadenoson with Simultaneous 13N-ammonia PET Validation in a Whole-body Hybrid PET/MR System

Hsin-Jung Yang¹, Damini Dey¹, Jane Sykes², John Butler², Xiaoming Bi³, Behzad Sharif¹, Sotirios Tsaftaris⁴, Debiao Li¹, Piotr Slomka¹, Frank Prato², and Rohan Dharmakumar¹

¹Cedars Sinai Medical Center, Los Angeles, CA, United States, ²Lawson Health Research Institute, london, ON, Canada, ³Siemens Healthcare, Los Angeles, CA, United States, ⁴IMT Institute for Advanced Studies Lucca, Lucca, Italy

Over the past two decades myocardial BOLD MRI has seen major technical advancements and a number of clinical validation studies. However, the reliability of BOLD MRI still remains a key weakness for its widespread adoption for routine clinical use due to the unpredictable motions during stress tests. We investigated whether the unique pharmocokinetics of regadenoson, a new coronary vasodilator that is rapidly becoming the agent of choice for cardiac stress testing, can be used to markedly improve the reliability of myocardial BOLD MRI. Studies were performed in a canine model and validated in a clinical PET/MR system.

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