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Abstract #1002

Comparison of perfusion signal acquired by ASL prepared IVIM and conventional IVIM to unravel the origin of the IVIM-signal

Xingxing Zhang1, Carson Ingo1, and Matthias J.P. van Osch1,2

1C. J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Leiden Institute for Brain and Cognition, Leiden, Netherlands

ASL-prepared IVIM is proposed to study the arterial IVIM signal as a function of post-labeling-delay. The D*-value as calculated from ASL-IVIM decreases as a function of PLD, reaching a plateau for PLDs>2000ms. Signal from conventional IVIM shows an intermediate D*-value corresponding to the ASL-IVIM-signal for a PLD of ~1750ms indicating the IVIM signal does not only originate from the microvasculature, but also includes vascular signal. The alternative explanation of extravasation of labeled spins into the extravascular compartment seems unlikely, since the observed D* at these PLDs are still a factor 3~4 higher than the diffusion coefficient of the slow compartment.

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