Daniel Arteaga1, Megan Strother1, Taylor Davis1, Carlos Faraco1, Lori Jordan2, Allison Scott1, and Manus Donahue1
1Radiology, Vanderbilt University, Nashville, TN, United States, 2Neurology, Vanderbilt University, Nashville, TN, United States
Non-invasive, hemodynamic markers are needed to better characterize stroke risk in patients with symptomatic intracranial (IC) stenosis. We developed and applied a planning-free vessel-encoded pseudo-continuous arterial spin labeling sequence in IC stenosis patients during room air and hypercapnia to examine the extent of geometrical changes in cerebral blood flow territories. IC stenosis patients demonstrated increased shifting relative to healthy controls; among IC stenosis patients, shifting was higher in those who experienced non-cardioembolic stroke within two-years. Shifting of cerebral blood flow territories may provide a novel marker of hemodynamic impairment and stroke risk.