Abstract #1004

Comparing Single-Delay, Sequential Multi-delay, and Hadamard Multi-delay ASL for Measuring CBF and Arterial Transit Delay in Normal Subjects and Patients with Cerebrovascular Disease

Samantha Holdsworth¹, Audrey Fan¹, Marc Lebel², Zungho Zun³, Ajit Shankaranarayanan⁴, and Greg Zaharchuk¹

¹Department of Radiology, Stanford University, Stanford, CA, United States, ²GE Healthcare, Calgary, Canada, ³George Washington University, Washington, DC, United States, ⁴GE Healthcare, Menlo Park, CA, United States

One promising approach to multi-delay ASL is to perform the labeling using a Hadamard-encoded method, which promises to improve the SNR efficiency compared with sequential multi-delay ASL. In this study, we compared single-delay ASL, sequential multi-delay ASL, and Hadamard-encoded multi-delay ASL in normal subjects and in patients with cerebrovascular disease. Consistent with theory, Hadamard-encoding had better SNR than sequential multi-delay ASL for measuring CBF and arterial transit delay.

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