Abstract #1005

Hypoglycemia-induced changes in global and regional cerebral blood flow; impact of type 1 diabetes and impaired awareness of hypoglycemia

Evita Wiegers¹, Kirsten Becker¹, Hanne Rooijackers², Cees Tack², Arend Heerschap¹, Bastiaan de Galan², and Marinette van der Graaf^1,3

¹Radiology and Nuclear Medicine, Radboud umc, Nijmegen, Netherlands, ²Internal Medicine, Radboud umc, Nijmegen, Netherlands, ³Pediatrics, Radboud umc, Nijmegen, Netherlands

Hypoglycemia-induced changes in global and regional cerebral blood flow (CBF) were investigated in patients with type 1 diabetes (T1DM) and impaired (IAH) or normal awareness of hypoglycemia (NAH) and in healthy subjects. CBF-weighted images were acquired using pseudo-continuous arterial spin labeling MRI. Global CBF increased in response to hypoglycemia in T1DM IAH subjects, but not in T1DM NAH or in healthy controls. Hypoglycemia induced regional relative increases in CBF in the thalamus of both T1DM NAH and healthy controls, and in the frontal lobes of T1DM NAH, while no such increases were found in the T1DM IAH group.

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