Meeting Banner
Abstract #1024

Assessment of Thrombus Stage by ‘Multicolor’ 19F MRI

Sebastian Temme1, Christoph Jacoby2, Christoph Owenier1, Christoph Grapentin3, Xiaowei Wang4, Rolf Schubert3, Karlheinz Peter4, Jürgen Schrader1, and Ulrich Flögel1,2

1Molecular Cardiology, University of Düsseldorf, Düsseldorf, Germany, 2Department of Cardiology, Pneumology and Angiology, University Hospital Düsseldorf, Düsseldorf, Germany, 3Pharmaceutical Technology and Biopharmacy, University of Freiburg, Freiburg i. Br., Germany, 4Atherothrombosis and Vascular Biology, Baker IDI Heart and Diabetes Institute, Victoria, Australia

The present study was aimed at developing a non-invasive approach for direct assessment of thrombus stage by ‘multicolor’ 19F MRI. To this end, we used ligands binding specifically during different phases of thrombosis and coupled them to perfluorocarbons (PFCs) with indvidual spectral signatures. Discrimination of the targeted agents was achieved by a novel multi chemical shift selective imaging technique for simultaneous, artifact-free detection of different PFCs. The results show that this technique holds the potential to differentiate thrombi in the acute, subacute and chronic phase and may also be used for in situ labeling of a variety of other targets.

This abstract and the presentation materials are available to members only; a login is required.

Join Here