Abstract #1024

Assessment of Thrombus Stage by ‘Multicolor’ 19F MRI

Sebastian Temme¹, Christoph Jacoby², Christoph Owenier¹, Christoph Grapentin³, Xiaowei Wang⁴, Rolf Schubert³, Karlheinz Peter⁴, Jürgen Schrader¹, and Ulrich Flögel^1,2

¹Molecular Cardiology, University of Düsseldorf, Düsseldorf, Germany, ²Department of Cardiology, Pneumology and Angiology, University Hospital Düsseldorf, Düsseldorf, Germany, ³Pharmaceutical Technology and Biopharmacy, University of Freiburg, Freiburg i. Br., Germany, ⁴Atherothrombosis and Vascular Biology, Baker IDI Heart and Diabetes Institute, Victoria, Australia

The present study was aimed at developing a non-invasive approach for direct assessment of thrombus stage by ‘multicolor’ ¹⁹F MRI. To this end, we used ligands binding specifically during different phases of thrombosis and coupled them to perfluorocarbons (PFCs) with indvidual spectral signatures. Discrimination of the targeted agents was achieved by a novel multi chemical shift selective imaging technique for simultaneous, artifact-free detection of different PFCs. The results show that this technique holds the potential to differentiate thrombi in the acute, subacute and chronic phase and may also be used for in situ labeling of a variety of other targets.

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