Abstract #1023

Label-free CEST MRI detection of self-assembly anticancer drug-peptide nanofibers

Yuguo Li^1,2, Lye Lin Lock³, Renyuan Bai⁴, Xinpei Mao³, Verena Staedtke⁵, Peter C.M Van Zijl^1,2, Honggang Cui^3,6, and Guanshu Liu^1,2

¹The Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, United States, ⁴Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, United States, ⁵Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, United States, ⁶Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, United States

A new injectable and CEST MRI-detectable nanofiber hydrogel has been developed for image-guided drug delivery of anticancer drug Pemetrexed (Pem). Such a drug delivery system is composed of only drug (Pem) and peptide (FFEE) and the MRI detectability stems on the inherent CEST signal of Pem. In the present study, PemFE nanofiber hydrogel was first constructed and characterized. Then, the CEST MRI detection of the constructed hydrogel in vivo was demonstrated in an orthotopic brain tumor mouse model. Our study clearly demonstrated the ability of using CEST MRI to monitor drug delivery of PemFE hydrogel.

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