Abstract #1026

Quantitative Evaluation of Tumour Associated Macrophages in Breast Cancer: Fluorine-19 versus Iron Oxide Nanoparticles

Ashley V Makela^1,2, Jeffrey M Gaudet^1,2, and Paula J Foster^1,2

¹Medical Biophysics, Western University, London, ON, Canada, ²Robarts Research Institute, London, ON, Canada

Tumour associated macrophages (TAMs) are correlated with an aggressive tumour type and poor outcomes. This study is the first time iron and fluorine-19 (¹⁹F) based MRI cell tracking methods have been compared for the detection and quantification of TAMs in an orthotopic model of breast cancer. Imaging was performed at 4 days and 3 weeks post cell implantation. Both cell tracking methods showed a much higher TAM density at 4 days; no other imaging study has examined this at such an early time point. ¹⁹F MRI provided quantitative information about TAM density and tumoural distribution that was not possible with iron.

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