Abstract #1027

Age-related changes in anterograde transport, axonal integrity and visuomotor function in the DBA/2J mouse model of chronic glaucoma

Xiao-Ling Yang^1,2, Yolandi van der Merwe^1,3, Leon C. Ho^1,4, Ian P. Conner^2,3, Seong-Gi Kim^1,5, Kira L. Lathrop², Gadi Wollstein^2,3, Joel S. Schuman^2,3, and Kevin C. Chan^1,2

¹NeuroImaging Laboratory, University of Pittsburgh, Pittsburgh, PA, United States, ²UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, United States, ³Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, United States, ⁴Department of Electrical and Electronic Engineering, University of Hong Kong, Pokfulam, Hong Kong, ⁵Center for Neuroscience Imaging Research, Institute for Basic Science, Sungkyunkwan University, Suwon, Korea, Republic of

Glaucoma is the leading cause of irreversible blindness worldwide and is a slowly progressing neurodegenerative disease of the visual system. While elevated intraocular pressure (IOP) and age are major risk factors, their effects on glaucoma pathogenesis remain incompletely understood. In this study, we determined the onset of glaucomatous changes and their progression in a chronic inherited glaucoma model using DBA/2J mice. Our results indicate that elevation of IOP may accelerate the deterioration of structure, physiology and function of the visual system in the DBA/2J mice across age. Comparatively, the visual system in C57BL/6J mice appeared intact across the same ages.

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