Abstract #1028

Characterizing Iron Oxide NanoParticles using 4D Spectroscopic SWIFT

Jinjin Zhang¹, Hattie L. Ring¹, Michael Garwood¹, and Djaudat Idiyatullin¹

¹Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States

The ability to accurately and sensitively quantify the bio-distribution of iron oxide nanoparticles is essential for their use as both diagnostic and therapeutic agents in theranostics. In this study, a 4D spectroscopic SWIFT technique was applied and optimized to characterize the distribution of IONPs in mouse invivo up to high concentration (>1.0 mg Fe/g of tissue). The frequency shift due to susceptibility variation and T₂* shortening (down to 20 μs) caused by IONPs were detected in mice organs depositing IONPs. The acquired T₂* map which provide quantitative information about IONP bio-distribution makes the 4D spectroscopic SWIFT a promising tool in nanoparticle-based theranostics.

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