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Abstract #1028

Characterizing Iron Oxide NanoParticles using 4D Spectroscopic SWIFT

Jinjin Zhang1, Hattie L. Ring1, Michael Garwood1, and Djaudat Idiyatullin1

1Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States

The ability to accurately and sensitively quantify the bio-distribution of iron oxide nanoparticles is essential for their use as both diagnostic and therapeutic agents in theranostics. In this study, a 4D spectroscopic SWIFT technique was applied and optimized to characterize the distribution of IONPs in mouse invivo up to high concentration (>1.0 mg Fe/g of tissue). The frequency shift due to susceptibility variation and T2* shortening (down to 20 μs) caused by IONPs were detected in mice organs depositing IONPs. The acquired T2* map which provide quantitative information about IONP bio-distribution makes the 4D spectroscopic SWIFT a promising tool in nanoparticle-based theranostics.

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