Abstract #1038

Relationship between neuropsychological stress and inflammation: a PET and MRI study.

Cheuk Ying Tang¹, Victoria X Wang², Johnny C Ng², Venkatesh Mani², Sarah Horn³, James Murrough³, Chloe Solomon², Willem Mulder², Valentin Fuster⁴, Dennis Charney⁵, Ahmed A Tawakol⁶, Lisa Shin⁷, Matthias Nahrendorf⁸, and Zahi A Fayad⁹

¹Radiology & Psychiatry, Translational and Molecular Imaging Institute at Mount Sinai, New York, NY, United States, ²Radiology, Translational and Molecular Imaging Institute at Mount Sinai, New York, NY, United States, ³Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁴Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁵Psychiatry, Neuroscience & Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁶Cardiology, Massachusetts General Hospital, Boston, MA, United States, ⁷Psychology, Tufts University, Medford, MA, United States, ⁸Center for Systems Biology, Massachusetts General Hospital, Boston, MA, United States, ⁹Radiology, Medicine & Cardiology, Translational and Molecular Imaging Institute at Mount Sinai, New York, NY, United States

We used both FDG PET and MRI to study the relationship between neuropsychological stress and inflammation in a PTSD population. Significant correlations between white matter fractional anisotropy and inflammation in the carotid as measured using FD-PET. Resting state scans and functional scans correlated with HAMA and MADRS but no relationship was detected with FDG-PET.

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