Abstract #1039

Glutathione and Glutamate in Schizophrenia: A 7T MRS Study

Jyothika Kumar¹, Emma L Hall², Siân E Robson², Carolina Fernandes², Elizabeth B Liddle¹, Matthew J Brookes², Lena Palaniyappan¹, Peter G Morris², and Peter F Liddle¹

¹Centre for Translational Neuroimaging, Division of Psychiatry and Applied Psychology, University of Nottingham, Nottingham, United Kingdom, ²Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom

Various theories of neurochemical dysfunction in schizophrenia have been proposed. Using 7T MR spectroscopy, we aim to investigate abnormalities in the antioxidant and glutamatergic systems in patients with schizophrenia and whether there is a relationship between the two. We found reduced levels of glutathione in the anterior cingulate cortex (ACC) in patients with residual schizophrenia indicating a reduction in the brain’s antioxidant defences accompanied by reduced levels of glutamate and glutamine. A positive correlation between glutathione and glutamate was observed in the ACC in all participants indicating a mechanistic link between these two systems.

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