Abstract #1051

Are Renal Lipids Increased in Overweight Diabetic Patients? A MR Spectroscopy and Dixon Fat/Water Imaging Study

Gaëlle Diserens¹, Waldo Valenzuela², Maryam Seif¹, Laila Mani³, Daniel Fuster³, Christoph Stettler⁴, Bruno Vogt³, Mauricio Reyes², Chris Boesch¹, and Peter Vermathen¹

¹Depts Clinical Research and Radiology, University of Bern, Bern, Switzerland, ²Institute for Surgical Technology and Biomechanics, University of Bern, Bern, Switzerland, ³Dept. of Nephrology, Hypertension and Clinical Pharmacology, University of Bern, Bern, Switzerland, ⁴Dept. of Endocrinology, Diabetes and Clinical Nutrition, University of Bern, Bern, Switzerland

Renal ectopic lipid accumulation may lead to kidney dysfunction. The study purpose was to determine (1) renal ectopic lipid content in overweight type-2 diabetic patients compared to (a) overweight non-diabetic patients and (b) lean volunteers by 1H-MRS and (2) renal sinus fat content by DIXON-MRI in the same three patient groups. This study demonstrates that renal ectopic lipids appear to be not higher in overweight diabetic patients compared to overweight non-diabetic subjects, while ectopic lipids are higher in both groups compared to healthy subjects. Significantly higher renal sinus bulk lipids were detected for overweight diabetic patients compared to BMI-matched non-diabetics.

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