Abstract #1056

Deep subcutaneous adipose tissue lipid unsaturation associates with intramyocellular lipid content

Jesper Lundbom^1,2, Alessandra Bierwagen^1,2, Kálmán Bodis^1,2, Jaakko Kaprio^3,4,5, Aila Rissanen^6,7, Nina Lundbom⁸, Michael Roden^1,2,9, and Kirsi Pietiläinen^4,6,10

¹German Diabetes Center, Leibniz Center for Diabetes Research, Düsseldorf, Germany, ²German Center for Diabetes Research (DZD e.V.), Partner Düsseldorf, Düsseldorf, Germany, ³Finnish Twin Cohort Study, Department of Public Health, Hjelt Institute, Helsinki, Finland, ⁴FIMM, Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland, ⁵National Institute for Health and Welfare, Helsinki, Finland, ⁶Obesity Research Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland, ⁷Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland, ⁸HUS Medical Imaging Center, University of Helsinki, Helsinki, Finland, ⁹Department of Endocrinology and Diabetology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany, ¹⁰Endocrinology, Abdominal Center, Helsinki University Central Hospital, Helsinki, Finland

The present study uses non-invasive MRS to examine whether MZ twins discordant for BMI display depot specific differences in adipose tissue unsaturation (DSAT and SSAT), and how the unsaturation relates to body fat distribution and ectopic fat. The main finding of the twin study is that DSAT lipid unsaturation associates with intramyocellular lipid content, which was further confirmed in a general population study and for the repeated sampling of one volunteer. These results highlight the role of fatty acid composition in adipose tissue - skeletal muscle crosstalk.

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