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Abstract #1058

Hepatic lipid alterations monitored by 1H-MRS in vivo in the ontogeny of obesity-related metabolic dysregulation.

Ana Francisca Soares1, João M. N. Duarte1, Blanca Lizarbe1, and Rolf Gruetter1,2,3,4

1Laboratory of Functional and Metabolic Imaging (LIFMET), Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland, 2Center for Biomedical Imaging (CIBM), Lausanne, Switzerland, 3Department of Radiology, University of Geneva (UNIGE), Geneva, Switzerland, 4Department of Radiology, University of Lausanne (Unil), Lausanne, Switzerland

Obesity is associated with a loss of metabolic control, largely driven by alterations in whole-body lipid distribution. Impaired insulin action leads to hepatic lipid accumulation and, conversely, high levels of liver lipids also cause insulin resistance. We followed the loss of glucose homeostasis in mice fed a high-fat diet for 18 weeks. In parallel, we assessed their hepatic lipids by 1H-MRS in vivo. In this model, glucose intolerance preceded hepatic lipid accumulation that then contributed to aggravate the phenotype. Moreover, fasting-induced hepatic lipid dynamics was hampered with high-fat diet feeding.

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