Abstract #1058

Hepatic lipid alterations monitored by 1H-MRS in vivo in the ontogeny of obesity-related metabolic dysregulation.

Ana Francisca Soares¹, João M. N. Duarte¹, Blanca Lizarbe¹, and Rolf Gruetter^1,2,3,4

¹Laboratory of Functional and Metabolic Imaging (LIFMET), Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland, ²Center for Biomedical Imaging (CIBM), Lausanne, Switzerland, ³Department of Radiology, University of Geneva (UNIGE), Geneva, Switzerland, ⁴Department of Radiology, University of Lausanne (Unil), Lausanne, Switzerland

Obesity is associated with a loss of metabolic control, largely driven by alterations in whole-body lipid distribution. Impaired insulin action leads to hepatic lipid accumulation and, conversely, high levels of liver lipids also cause insulin resistance. We followed the loss of glucose homeostasis in mice fed a high-fat diet for 18 weeks. In parallel, we assessed their hepatic lipids by ¹H-MRS in vivo. In this model, glucose intolerance preceded hepatic lipid accumulation that then contributed to aggravate the phenotype. Moreover, fasting-induced hepatic lipid dynamics was hampered with high-fat diet feeding.

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