Abstract #1059

TOFI – Thin Outside, Fat Inside – identifying non-obese subjects at high risk for metabolic diseases based on MRI and MRS

Jürgen Machann¹, Malte Niklas Bongers², Norbert Stefan³, Andreas Fritsche³, Konstantin Nikolaou⁴, Hans-Ulrich Häring³, and Fritz Schick⁵

¹Section on Experimental Radiology, IDM of the Helmholtz Center Munich at the University Tübingen, German Center for Diabetes Research (DZD), Tuebingen, Germany, ²Department of Diagnostic and Interventional Radiology, Section on Experimental Radiology, Tuebingen, Germany, ³Department of Endocrinology and Diabetology, Angiology, Nephrology and Clinical Chemistry, IDM of the Helmholtz Center Munich at the University Tübingen, German Center for Diabetes Research (DZD), Tuebingen, Germany, ⁴Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tuebingen, Germany, ⁵Section on Experimental Radiology, University Hospital Tübingen, Tuebingen, Germany

Axial T1-weighted MRI and volume selective ¹H-MRS were performed in a cohort of almost 500 non-obese subjects at increased risk for metabolic diseases. Adipose (AT) and lean tissue (LT) compartments from different body regions were quantified and are expressed as percentage of the entire volume in order to display tissue distribution and to differentiate metabolically healthy (insulin sensitive, IS) and unhealthy (insulin resistant, IR) subgroups. Additionally, intrahepatic lipids (IHL) were quantified. It could be shown that IS subjects are characterized by lower percentage of AT in abdominal regions but higher amounts in the extremities whereas IHL are almost doubled in IR subjects.

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