Abstract #1063

High spatial and temporal resolution DCE-MRI of intervertebral disc endplates using GRAPPA accelerated 3D-Linogram acquisition

L. Tugan Muftuler^1,2, Ali Ersoz³, and Volkan Emre Arpinar¹

¹Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States, ²Center for Imaging Research, Medical College of Wisconsin, Milwaukee, WI, United States, ³Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States

It is suggested that disruption of nutrient delivery through the intervertebral disc endplates could lead to physiological and morphological changes in the discs. Our earlier DCE-MRI studies demonstrated major changes in endplate regions. However, we had to sacrifice temporal resolution to obtain high spatial resolution to image the thin endplates. Higher temporal resolution is needed for quantitative analysis of tracer kinetics. Therefore, we developed and tested 3D-Linogram acquisition technique that allowed higher temporal resolution and reduced motion artifacts. Tofts’ tracer kinetic model was implemented and Ktrans values from vertebral endplates were estimated.

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