Abstract #1071

High Resolution MRI for Characterization of Inflammation within Abdominal Aortic Aneurysm

Chengcheng Zhu¹, Thomas Hope¹, Henrik Haraldsson¹, Farshid Faraji¹, David Saloner¹, and Michael Hope¹

¹Radiology, University of California, San Francisco, San Francisco, CA, United States

Abdominal aortic aneurysms (AAAs) with focal inflammation (identified by USPIO uptake) have been reported to predict faster growth. Previous 2D T2* mapping method is limited by spatial resolution. This study evaluated 3D high-resolution techniques (up to 1.3mm isotropic) for inflammation imaging of AAAs. Experiments were preformed using both USPIO phantoms and in vivo patient studies. We found the signal characteristics of 3D DANTE-SPACE images had good agreement with T2* value drop, and it provided higher resolution and possible information on USPIO concentration. Therefore, 3D high resolution methods may help risk stratify patients with AAA disease by characterizing and quantifying inflammation.

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