Abstract #1072

Robust large-volume fat suppression in whole-heart free-breathing self-navigated coronary MR angiography at 3T using lipid insensitive binomial off-resonant excitation (LIBRE) pulses

Jessica AM Bastiaansen¹, Davide Piccini^1,2, Ruud B van Heeswijk^1,3, and Matthias Stuber^1,3

¹Department of Radiology, University hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, ²Advanced Clinical Imaging Technology, Siemens Healthcare, Lausanne, Switzerland, ³Center for Biomedical Imaging, Lausanne, Switzerland

Large volume fat suppression is increasingly challenging at high magnetic field strengths due to B₀ and B₁ inhomogeneities. In this study, we developed a novel lipid-insensitive binomial off-resonant (LIBRE) radiofrequency excitation pulse to achieve near-complete fat suppression in large 3D volumes and applied it to whole-heart coronary imaging at 3T. In 6 healthy volunteers, we performed free-breathing self-navigated whole-heart 3D radial coronary MRA, and quantitatively compared the results to more commonly used methods for lipid nulling. We show that LIBRE significantly improves the signal nulling of lipid resonances resulting in both improved blood pool delineation for self-navigation and increased vessel conspicuity in the final images.

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