Abstract #1075

Model-based characterization of the transpulmonary circulation by DCE-MRI

Salvatore Saporito¹, Ingeborg H.F. Herold ^1,2, Patrick Houthuizen³, Jacques A. den Boer¹, Harrie C.M. van den Bosch⁴, Hendrikus H.M. Korsten ^1,2, Hans C. van Assen¹, and Massimo Mischi¹

¹Department of Electrical Engineering, Eindhoven University of technology, Eindhoven, Netherlands, ²Department of Anesthesiology and Intensive Care, Catharina Hospital Eindhoven, Eindhoven, Netherlands, ³Department of Cardiology, Catharina Hospital Eindhoven, Eindhoven, Netherlands, ⁴Department of Radiology, Catharina Hospital Eindhoven, Eindhoven, Netherlands

Objective measures to assess pulmonary circulation status would improve heart failure patient care. We propose a method for the characterization of the transpulmonary circulation by DCE-MRI. Parametric deconvolution was performed between contrast agent first passage time-enhancement curves derived from the right and left ventricular blood pool. The transpulmonary circulation was characterized as a linear system with impulse response modelled as local density random walk model. We tested the method on 32 heart failure patients and 19 healthy volunteers; patients presented longer transpulmonary transit times and more skewed transpulmonary impulse responses.

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