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Abstract #1076

Predictive Bolus Tailoring of Gd-Based Contrast Agents for Optimized Contrast-Enhanced MRA

Jeffrey H Maki1 and Gregory J Wilson1

1Radiology, University of Washington, Seattle, WA, United States

Gadolinium contrast for CE-MRA is typically injected at a fixed, relatively fast (1.5 – 2.0 mL/s) rate. This results in a peaked bolus profile such that vascular signal intensity (SI) decays during latter k-space acquisition, leading to blurring and ringing artifacts. A “tailored” test bolus-based predictive algorithm was developed to determine a patient-individualized multi-phase injection to achieve any arbitrary arterial SI “plateau” duration. This technique was tested on 10 patients and compared to 10 patients receiving a fixed 1.6 mL/s contrast injection. The tailored bolus plateau duration was 24 vs. 9 s (p < 0.01) with only a 20% SI loss.

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