Abstract #1082

Chronic mild stress induces changes in neurite density in the amygdala as revealed by diffusion MRI and validated with novel histological analyses

Ahmad Raza Khan¹, Andery Chuhutin¹, Ove Wiborg², Christopher D Kroenke³, Jens R Nyengaard⁴, Brian Hansen¹, and Sune Nørhøj Jespersen^1,5

¹Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark, ²Centre for Psychiatric Research, Aarhus University, Aarhus, Denmark, ³Advanced Imaging Research Center, Portland, OR, United States, ⁴Stereology and Electron Microscopy Laboratory, Aarhus University, Aarhus, Denmark, ⁵Department of Physics and Astronomy, Aarhus University, Aarhus, Denmark

Biophysical modelling of diffusion MRI data allows detection of specific tissue microstructures such as neurite density. However, histological validation of MR-derived indication of microstructural alteration is limited due extensive time labour and invasive character, even though histological validation is crucial because it remains the gold standard. The present study applies Matlab based image processing and analysis tools to compute histological neurite density to validate diffusion MRI based neurite density changes in the amygdala of chronic mild stress rat brains. The image processing and analyses provides novel tools to validate diffusion data robustly.

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