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Abstract #1083

Altered hippocampal microstructure in the epileptogenic rat brain revealed with diffusion MRI using oscillating field gradients

Manisha Aggarwal1, Olli Gröhn2, and Alejandra Sierra2

1Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Department of Neurobiology, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland

We investigate changes in the temporal diffusion spectrum sampled using oscillating gradient spin-echo (OGSE) acquisitions at increasing gradient frequencies in the epileptogenic rat brain. PGSE and OGSE data at discrete oscillation frequencies were acquired from pilocarpine-treated and control rat brains (n=5 each) with a spectral resolution of 60 Hz (f = 60 Hz, 120 Hz, 180 Hz). Our findings reveal significant changes in the frequency-dependent modulation of apparent diffusion coefficient (ADC) in specific areas of the pilocarpine brain, which were found to correspond to region-specific gliosis and neuronal loss respectively. Using comparison with histological findings, our results show unique sensitivity of OGSE diffusion MRI to probe specific cellular-level alterations in the epileptogenic brain.

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