Abstract #1083

Altered hippocampal microstructure in the epileptogenic rat brain revealed with diffusion MRI using oscillating field gradients

Manisha Aggarwal¹, Olli Gröhn², and Alejandra Sierra²

¹Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Department of Neurobiology, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland

We investigate changes in the temporal diffusion spectrum sampled using oscillating gradient spin-echo (OGSE) acquisitions at increasing gradient frequencies in the epileptogenic rat brain. PGSE and OGSE data at discrete oscillation frequencies were acquired from pilocarpine-treated and control rat brains (n=5 each) with a spectral resolution of 60 Hz (f = 60 Hz, 120 Hz, 180 Hz). Our findings reveal significant changes in the frequency-dependent modulation of apparent diffusion coefficient (ADC) in specific areas of the pilocarpine brain, which were found to correspond to region-specific gliosis and neuronal loss respectively. Using comparison with histological findings, our results show unique sensitivity of OGSE diffusion MRI to probe specific cellular-level alterations in the epileptogenic brain.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.