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Abstract #1084

Detecting Disrupted-in-Schizophrenia-1 Gene Related Microstructural and Molecular Alterations using Diffusion Kurtosis Imaging and Quantitative Susceptibility Mapping

Nan-Jie Gong1, Russell Dibbs2, Kyle Decker2, Mikhail V. Pletnikov3, and Chunlei Liu1

1Brain Imaging and Analysis Center, Duke University, Durham, NC, United States, 2Center for In Vivo Microscopy, Duke University, Durham, NC, United States, 3Behavioral Neurobiology and Neuroimmunology Laboratory, Johns Hopkins University, Baltimore, MD, United States

DKI method provided sensitive metrics for reflecting microstructural changes in not only the anterior commissure but also relatively isotropic gray matter regions of hippocampus, cerebral cortex and caudate putamen. Further relating DKI findings to molecular compositions measured by QSM enabled clearer interpretations of myelin content and cellular density related mechanisms. Further validations that establish the relationship between imaging metrics and histological measurements such as neuronal cell body density, myelin thickness and g-ratio are needed.

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