Abstract #1084

Detecting Disrupted-in-Schizophrenia-1 Gene Related Microstructural and Molecular Alterations using Diffusion Kurtosis Imaging and Quantitative Susceptibility Mapping

Nan-Jie Gong¹, Russell Dibbs², Kyle Decker², Mikhail V. Pletnikov³, and Chunlei Liu¹

¹Brain Imaging and Analysis Center, Duke University, Durham, NC, United States, ²Center for In Vivo Microscopy, Duke University, Durham, NC, United States, ³Behavioral Neurobiology and Neuroimmunology Laboratory, Johns Hopkins University, Baltimore, MD, United States

DKI method provided sensitive metrics for reflecting microstructural changes in not only the anterior commissure but also relatively isotropic gray matter regions of hippocampus, cerebral cortex and caudate putamen. Further relating DKI findings to molecular compositions measured by QSM enabled clearer interpretations of myelin content and cellular density related mechanisms. Further validations that establish the relationship between imaging metrics and histological measurements such as neuronal cell body density, myelin thickness and g-ratio are needed.

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