Abstract #1099

Adiabatic excitation for 31P spectroscopy in the human heart at 7T

Ladislav Valkovič^1,2, William T Clarke¹, Benoit Schaller¹, Lucian A B Purvis¹, Stefan Neubauer¹, Ivan Frollo², Matthew D Robson¹, and Christopher T Rodgers¹

¹Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom, ²Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia

³¹P-MRS is of particular interest in cardiovascular medicine, as the PCr/ATP ratio can serve as a predictor of mortality. However, due to inherently low signal-to-noise ratio (SNR), cardiac ³¹P-MRS is not yet practical in the clinic. To increase SNR, the use of 7T and dedicated receive arrays has been proposed. However, the peak B₁⁺ was inadequate for the use of B₁ insensitive pulses, thus far. In this study, we demonstrate the feasibility of homogeneous adiabatic excitation for cardiac ³¹P-MRS using a novel quadrature ³¹P transceiver at 7T. This constitutes an important step towards absolute quantification of cardiac metabolites at 7T.

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