Abstract #1100

Improvement of Quantification of 1H Cardiac MR Spectra Acquired at 3T by the Use of Prior Knowledge

Ariane Fillmer^1,2, Andreas Hock^2,3, and Anke Henning^2,4

¹Physikalisch Technische Bundesanstalt (PTB), Berlin, Germany, ²Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, ³Department of Psychiatry, Psychotherapy and Psychosomatics, Hospital of Psychiatry, University of Zurich, Zurich, Switzerland, ⁴Max Planck Institute for Biological Cybernetics, Tuebingen, Germany

¹H cardiac MRS is a promising tool for investigation of human heart disease. In this context the independent quantification of intramyocellular (IMCL) and extramyocellular lipids (EMCL) is desired. Quantification itself, however, remains challenging. This work investigates, whether quantification of metabolite signals within ¹H cardiac MR spectra could be improved by the use of prior knowledge about the behavior of metabolite signals in the quantification process.

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