Abstract #1101

3D resolved human cardiac creatine kinase rate by 31P-MRS at 7T.

William Thomas Clarke¹, Matthew D Robson¹, and Christopher T Rodgers¹

¹Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom

The creatine kinase (CK) forward rate constant k_f is a sensitive biomarker for heart failure. However, the low SNR of ³¹P-MRS at 1.5T and 3T has only allowed it to be measured at low spatial resolution by 1D-CSI. Here, we show how cardiac 7T ³¹P-MRS permits 3D resolved measurements for the first time. A 3D variant of the FAST k_f^CKmethod was combined with ³¹P Bloch-Siegert B₁⁺ mapping to enable 3D-resolved measurements at 7T. The first measurements of the creatine kinase rate in myocardium in the interventricular septum are obtained from four subjects. Our mean k_f = 0.36±0.04 s^-1 was consistent with literature values.

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