Abstract #1102

Second-Order Motion-Compensated PRESS for Cardiac Spectroscopy

Maximilian Fuetterer¹, Christian Torben Stoeck^1,2, and Sebastian Kozerke^1,2

¹Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, ²Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom

Second-order motion compensation for PRESS (PRESS^mc) is proposed to allow for robust single-voxel cardiac spectroscopy throughout the entire cardiac cycle. Motion-compensated spoiler gradients were designed and implemented into a cardiac-triggered PRESS sequence. A numerical 3D model of cardiac motion was used to optimize and validate the gradient waveforms. In-vivo measurements in healthy volunteers were obtained to assess SNR and triglyceride-to-water ratio (TG/W). SNR gains and variability of TG/W of PRESS^mc were evaluated against a conventional PRESS sequence with optimized gradients. PRESS^mc effectively reduces cardiac-motion induced signal degradation during FID spoiling providing higher SNR and less variability for TG/W quantification.

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