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Abstract #1102

Second-Order Motion-Compensated PRESS for Cardiac Spectroscopy

Maximilian Fuetterer1, Christian Torben Stoeck1,2, and Sebastian Kozerke1,2

1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, 2Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom

Second-order motion compensation for PRESS (PRESSmc) is proposed to allow for robust single-voxel cardiac spectroscopy throughout the entire cardiac cycle. Motion-compensated spoiler gradients were designed and implemented into a cardiac-triggered PRESS sequence. A numerical 3D model of cardiac motion was used to optimize and validate the gradient waveforms. In-vivo measurements in healthy volunteers were obtained to assess SNR and triglyceride-to-water ratio (TG/W). SNR gains and variability of TG/W of PRESSmc were evaluated against a conventional PRESS sequence with optimized gradients. PRESSmc effectively reduces cardiac-motion induced signal degradation during FID spoiling providing higher SNR and less variability for TG/W quantification.

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