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Abstract #1103

Mapping of pH in the human calf muscle at 7 T with 31P 3D echo–planar spectroscopic imaging

Andreas Korzowski1 and Peter Bachert1

1Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany

The tissue–pH value is an important parameter to assess physiological function. The purpose of this work was to explore the potential of three-dimensional 31P–{1H} echo–planar spectroscopic imaging at B0 = 7 T for mapping of intracellular pH in the human calf muscle with high spatial resolution. The acquired data demonstrate that the proposed method allows the robust quantification of intracellular pH value of voxels with less than 1 ml volume and therefore may give insight into the pH heterogeneity of different muscle groups.

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