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Abstract #1105

Observation of 31P magnetization transfer at 3 Tesla using asymmetric adiabatic inversion and two different fitting strategies.

Bertrand Pouymayou1, Tania Buehler1, Roland Kreis1, and Chris Boesch1

1Depts. Radiology and Clinical Research, University of Bern, Bern, Switzerland

31P-MR spectroscopy inversion transfer (IT) is increasingly investigated as a complementary method to study ATP-synthesis and creatine kinase in vivo. Three aspects of the IT experiment are studied here, in a test-retest design (12 volunteers, resting vastus muscle): the ability to produce an efficient half band inversion in vivo with a short asymmetric adiabatic pulse, the repeatability of the kinetic parameters estimation at 3T and the impact of two different fitting strategies (individual spectrum vs. two-dimensional fitting). As a result, k[Pi>γ-ATP] can be reliably estimated within cohorts while k[PCr>γ-ATP] is accurate enough to be distinguished between individuals.

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