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Abstract #1106

Localized 31P magnetization transfer in the rat brain to measure ATP synthesis rate: inorganic phosphate comes in two pools

Brice Tiret1,2, Vincent Lebon1,2, Emmanuel Brouillet1,2, and Julien Valette1,2

1CEA/DSV/I2BM/MIRCen, Fontenay-aux-Roses, France, 2CNRS Université Paris-Saclay UMR 9199, Fontenay-aux-Roses, France

Localized 31P MRS with progressive saturation transfer was performed in the rat brain to estimate the exchange rate between inorganic phosphate (Pi) and adenosine-tri-phosphate (ATP). It was found that two Pi pools, tentatively intra and extracellular pools, can be resolved at 11.7 T, and that only the intracellular Pi signal varies with progressive saturation, while the extracellular Pi signal remains constant. Not resolving this extracellular Pi can cause a significant bias in the estimation of the forward constant rate of ATP synthesis.

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