Abstract #1107

Dynamic 31P MRSI with spiral readout for quantification of mitochondrial capacity in muscles of the calf during plantar flexion exercise at 7T

Ladislav Valkovič^1,2,3,4, Marek Chmelík^1,2, Martin Meyerspeer^1,5, Borjan Gagoski⁶, Martin Krššák^1,2,7, Christopher T Rodgers⁴, Ivan Frollo³, Ovidiu C Andronesi⁸, Siegfried Trattnig^1,2,9, and Wolfgang Bogner^1,2

¹High-field MR Centre, Medical University of Vienna, Vienna, Austria, ²Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ³Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, ⁴Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom, ⁵Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria, ⁶Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, United States, ⁷Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, ⁸Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, ⁹Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria

Typically, only rough localization by the sensitive volume of the surface coil is used for dynamic ³¹P-MRS. However, such localization often mixes signals from several muscle groups. Available single-muscle localization techniques (e.g., semi-LASER or DRESS) provide only limited coverage and current ³¹P-MRSI techniques suffer from slow acquisition. To overcome the low temporal resolution of the standard ³¹P-MRSI, caused by slow Cartesian readout, we have developed, and tested in healthy subjects at 7T, a³¹P-MRSI sequence using spiral readout trajectory. This sequence enables spatially resolved quantification of mitochondrial capacity in several investigated muscles (e.g., GM, GL and SOL) simultaneously at 7T.

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