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Abstract #1115

Multi-sequence non-contrast MRI characterization of deep vein thrombosis in man

Alkystis Phinikaridou1, Prakash Saha2, Marcelo Andia3, Alberto Smith2, and René M Botnar1

1Biomedical Engineering, King's College London, London, United Kingdom, 2Academic Surgery, King's College London, London, United Kingdom, 3Radiology, Pontificia Universidad Católica de Chile, Santiago, Chile

Deep vein thrombosis (DVT) affects 1 in 1000 people. Its sequelae include post-thrombotic syndrome (PTS), which affects up to 75% of patients within 5 years and is characterised by persistent pain, swelling and ulceration. Thrombolysis can reduce PTS by a third and is attempted in patients with an ilio-femoral DVT and symptom onset of <3weeks. Determining age and thrombus structure by history alone is, however, subjective and there are no established methods to quantify the abundance of matrix proteins, which determines the response to lysis. This treatment is therefore only effective in ~60% of patients, which may unnecessarily exposes to haemorrhagic side effects. We have developed a non-contrast enhanced magnetic resonance, multi-sequence thrombus imaging (MSTI) technique that can provide information about the structural composition of experimental thrombus [1-2]. Here, we aim in translating the MRI approach into man and determine whether it can help guide venous intervention.

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