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Abstract #1117

Correlation between MRI-derived water content and conductivity in tumour and healthy tissue: how much cell water is active?

Ana-Maria Oros-Peusquens1, Yupeng Liao1, and N. Jon Shah1

1INM-4, Research Centre Juelich, Juelich, Germany

About 80% of brain water is found inside the cells and a large fraction of it is interfacial water with properties substantially different from those of bulk water. Evidence for a large osmotically unresponsive compartment, available from literature, is substantiated by the finding that a very large fraction of brain water does not contribute to its electrical conductivity. This is determined by investigating the correlation between conductivity and water content in tumour patients in vivo. More than 80% of brain water is found to be unresponsive, with variations reflecting tissue and tumour type. This work describes a noninvasive method for the characterisation of a deeply microscopic parameter of the living tissue.

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