Abstract #1137

Developing In Vivo Perfusion Imaging Methods for Spinal Cord Using Hyperpolarized [13C]t-Butanol and [13C, 15N2]Urea

Ilwoo Park¹, Jeremy Gordon¹, Sarah Nelson^1,2, and Jason Talbott^1,3

¹Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ²Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, United States, ³Brain and Spine Injury Center (BASIC), University of California San Francisco, San Francisco, CA, United States

This study has demonstrated the feasibility of using hyperpolarized ¹³C MRI with [¹³C]t-butanol and [¹³C,¹⁵N₂]urea for assessing in vivo perfusion in the cervical spinal cord. T-butanol rapidly crossed the blood-brain-barrier and diffused into spine and brain tissue, while urea predominantly remained in vasculature. The results from this study suggest that this technique may provide unique non-invasive imaging tracers that are able to directly monitor hemodynamic processes in the normal and injured spinal cord.

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