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Abstract #1137

Developing In Vivo Perfusion Imaging Methods for Spinal Cord Using Hyperpolarized [13C]t-Butanol and [13C, 15N2]Urea

Ilwoo Park1, Jeremy Gordon1, Sarah Nelson1,2, and Jason Talbott1,3

1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, United States, 3Brain and Spine Injury Center (BASIC), University of California San Francisco, San Francisco, CA, United States

This study has demonstrated the feasibility of using hyperpolarized 13C MRI with [13C]t-butanol and [13C,15N2]urea for assessing in vivo perfusion in the cervical spinal cord. T-butanol rapidly crossed the blood-brain-barrier and diffused into spine and brain tissue, while urea predominantly remained in vasculature. The results from this study suggest that this technique may provide unique non-invasive imaging tracers that are able to directly monitor hemodynamic processes in the normal and injured spinal cord.

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