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Abstract #1138

Clinical evaluation of the respiratory mechanics using accelerated 3D dynamic free breathing MRI reconstruction

Sampada Bhave1, Sajan Goud Lingala2, Scott Nagle3, John D Newell Jr4, and Mathews Jacob1

1Electrical and Computer Engineering, University of Iowa, Iowa City, IA, United States, 2Electrical Engineering, University of Southern California, Los Angeles, CA, United States, 3Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States, 4Radiology, University of Iowa, Iowa City, IA, United States

Three-dimensional dynamic MRI (3D-DMRI) is a promising method to analyze respiratory mechanics. However, current 3D DMRI implementations offer limited temporal, spatial resolution and volume coverage. In this work we demonstrate the feasibility of three compressed sensing reconstruction methods along with view-sharing method with clinical evaluation on 8 healthy subjects by expert radiologists. BCS scheme provides better performance than other schemes both qualitatively and quantitatively. The preliminary results on lung volume changes demonstrate the clinical utility of the BCS scheme.

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