Abstract #1140

Real-time dynamic fluorinated gas MRI in free breathing for mapping of regional lung ventilation in patients with COPD and healthy volunteers using a 16 channel receive coil at 1.5T

Marcel Gutberlet^1,2, Till Kaireit^1,2, Andreas Voskrebenzev^1,2, Julia Freise³, Tobias Welte³, Frank Wacker^1,2, and Jens Vogel-Claussen^1,2

¹Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, ²Plattform Imaging, German Centre for Lung Research (DZL), Hannover, Germany, ³Clinic of Pneumology, Hannover Medical School, Hannover, Germany

Quantification of regional lung ventilation is of high relevance for several lung diseases like chronic obstructive lung disease (COPD) or asthma. In this study real-time dynamic fluorinated gas MRI in free breathing for mapping of regional lung ventilation was applied in patients with COPD and healthy volunteers. A significant difference of washout kinetics between healthy volunteers and COPD patients was found. Dynamic fluorinated gas MRI highly correlated with lung function test which is used for COPD classification.

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