Abstract #1141

Quantitative Susceptibility Mapping of the Lungs with Multi-echo Radial MRI: Sensitivity to Pulmonary Oxygen Content

Zackary I. Cleveland^1,2, Jinbang Guo^1,3, Teckla Akinyi^1,2, Hongjiang Wei⁴, S. Sivaram Kaushik⁵, Jason C. Woods^1,3, Chunlei Liu⁴, Vivian S. Lee⁶, and Luke Xie⁶

¹1) Center for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ²2) Department of Biomedical, Chemical, and Environmental Engineering, University of Cincinnati, Cincinnati, OH, United States, ³3) Department of Physics, Washington University, St. Louis, MO, United States, ⁴Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC, United States, ⁵Medical College of Wisconsin, Milwaukee, WI, United States, ⁶6) Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, UT, United States

Magnetic susceptibility differences at gas-tissue interfaces within the lungs have long been considered a significant obstacle to performing high-resolution pulmonary MRI because of the resulting rapid T₂^* relaxation. However, susceptibility differences in the lungs originate from regional differences in blood oxygenation and alveolar O₂ content. Thus, if these differences are mapped, they have the potential to provide fundamental information about regional lung function. Here we demonstrate that quantitative susceptibility mapping (QSM) of the lungs is possible in vivo using multi-echo radial MRI. Additionally, we demonstrate that the contrast observed in the lungs via QSM is sensitive to O2 partial pressure.

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