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Abstract #1143

Ventilation Estimates in Severe Uncontrolled Asthma using 3D Single breath-hold Ultra-short Echo Time MRI

Khadija Sheikh1, Fumin Guo1, Alexei Ouriadov1, Dante PI Capaldi1, Sarah Svenningsen1, Miranda Kirby2, David G McCormack3, Harvey O Coxson2, and Grace Parraga1

1Robarts Research Institute, The University of Western Ontario, London, ON, Canada, 2UBC Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada, 3Department of Medicine, The University of Western Ontario, London, ON, Canada

To accelerate clinical translation of pulmonary proton UTE MRI, the underlying structural determinants of UTE MR signal-intensity must be determined. We regionally evaluated multi-volume UTE maps with direct comparison to thoracic CT in subjects with asthma. UTE MRI signal-intensity was related to CT radio-density, with a trend towards significance for pulmonary function tests, suggesting that changes in signal-intensity may reflect gas-trapping. This is important, because UTE signal-intensity measurements may be used to identify regions of gas-trapping/ventilation abnormalities in severe asthma without the use of inhaled-gas contrast or ionizing radiation making this approach suitable for children where longitudinal monitoring may be required.

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