Abstract #1143

Ventilation Estimates in Severe Uncontrolled Asthma using 3D Single breath-hold Ultra-short Echo Time MRI

Khadija Sheikh¹, Fumin Guo¹, Alexei Ouriadov¹, Dante PI Capaldi¹, Sarah Svenningsen¹, Miranda Kirby², David G McCormack³, Harvey O Coxson², and Grace Parraga¹

¹Robarts Research Institute, The University of Western Ontario, London, ON, Canada, ²UBC Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada, ³Department of Medicine, The University of Western Ontario, London, ON, Canada

To accelerate clinical translation of pulmonary proton UTE MRI, the underlying structural determinants of UTE MR signal-intensity must be determined. We regionally evaluated multi-volume UTE maps with direct comparison to thoracic CT in subjects with asthma. UTE MRI signal-intensity was related to CT radio-density, with a trend towards significance for pulmonary function tests, suggesting that changes in signal-intensity may reflect gas-trapping. This is important, because UTE signal-intensity measurements may be used to identify regions of gas-trapping/ventilation abnormalities in severe asthma without the use of inhaled-gas contrast or ionizing radiation making this approach suitable for children where longitudinal monitoring may be required.

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