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Abstract #1144

Pulmonary Phase Imaging using Self-Gated Fourier Decomposition MRI in Patients with Cystic Fibrosis

Simon Veldhoen1, Andreas Max Weng1, Clemens Wirth1, Andreas Steven Kunz1, Janine Nicole Knapp1, Daniel Stäb1,2, Florian Segerer3, Helge Uwe Hebestreit3, Thorsten Alexander Bley1, and Herbert Köstler1

1Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany, 2The Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia, 3Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany

Fourier Decomposition MRI provides functional lung imaging. Perfusion-weighted data carries information regarding the delay of maximal signal increase in the lung parenchyma during a cardiac cycle (pulmonary phase). Purpose of the study is to compare the pulmonary phase dispersion of cystic fibrosis (CF) patients and healthy controls. Functional maps were visually compared, phase values of the parenchyma were plotted on histograms and a peak-to-offset ratio was calculated. Ratios of CF patients were correlated with the forced expiratory volume (FEV1). CF patients showed more inhomogeneous maps and a significantly lower ratio (15.9±17.5 vs. 38.7±27.9, p=0.005), which correlated with their FEV1 (rs=0.72;p=0.001).

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