Simon Veldhoen1, Andreas Max Weng1, Clemens Wirth1, Andreas Steven Kunz1, Janine Nicole Knapp1, Daniel Stäb1,2, Florian Segerer3, Helge Uwe Hebestreit3, Thorsten Alexander Bley1, and Herbert Köstler1
1Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany, 2The Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia, 3Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany
Fourier
Decomposition MRI provides functional lung imaging. Perfusion-weighted data carries
information regarding the delay of maximal signal increase in the lung
parenchyma during a cardiac cycle (pulmonary phase). Purpose of the study is to
compare the pulmonary phase dispersion of cystic fibrosis (CF) patients and healthy
controls. Functional maps were visually compared, phase values of the
parenchyma were plotted on histograms and a peak-to-offset ratio was
calculated. Ratios of CF patients were correlated with the forced expiratory
volume (FEV1). CF patients showed more inhomogeneous maps and a significantly
lower ratio (15.9±17.5 vs. 38.7±27.9, p=0.005), which correlated with their FEV1 (rs=0.72;p=0.001).
