Abstract #1144

Pulmonary Phase Imaging using Self-Gated Fourier Decomposition MRI in Patients with Cystic Fibrosis

Simon Veldhoen¹, Andreas Max Weng¹, Clemens Wirth¹, Andreas Steven Kunz¹, Janine Nicole Knapp¹, Daniel Stäb^1,2, Florian Segerer³, Helge Uwe Hebestreit³, Thorsten Alexander Bley¹, and Herbert Köstler¹

¹Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany, ²The Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia, ³Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany

Fourier Decomposition MRI provides functional lung imaging. Perfusion-weighted data carries information regarding the delay of maximal signal increase in the lung parenchyma during a cardiac cycle (pulmonary phase). Purpose of the study is to compare the pulmonary phase dispersion of cystic fibrosis (CF) patients and healthy controls. Functional maps were visually compared, phase values of the parenchyma were plotted on histograms and a peak-to-offset ratio was calculated. Ratios of CF patients were correlated with the forced expiratory volume (FEV₁). CF patients showed more inhomogeneous maps and a significantly lower ratio (15.9±17.5 vs. 38.7±27.9, p=0.005), which correlated with their FEV₁ (r_s=0.72;p=0.001).

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